A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.

Correct interactions with extracellular matrix are essential to human pluripotent stem cells (hPSC) to maintain their pluripotent self-renewal capacity during in vitro culture. hPSCs secrete laminin 511/521, one of the most important functional basement membrane components, and they can be maintaine...

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Bibliographic Details
Main Authors: Sanna Vuoristo, Sanna Toivonen, Jere Weltner, Milla Mikkola, Jarkko Ustinov, Ras Trokovic, Jaan Palgi, Riikka Lund, Timo Tuuri, Timo Otonkoski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788803?pdf=render