Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thiophenes in the context of a rare remote asymmetric...

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Bibliographic Details
Main Authors: Xingguang Li, Meng Duan, Peiyuan Yu, K. N. Houk, Jianwei Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25165-7