Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium

Mice deficient in glutathione peroxidase (GPx)-1 and -2 (GPx1-/-GPx2-/- double knockout or DKO mice) develop very-early-onset (VEO) ileocolitis, suggesting that lack of defense against reactive oxygen species (ROS) renders susceptibility to intestinal inflammation. Two members of ROS-generating NADP...

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Bibliographic Details
Main Authors:	Fong-Fong Chu, R. Steven Esworthy, James H. Doroshow, Helmut Grasberger, Agnes Donko, Thomas L. Leto, Qiang Gao, Binghui Shen
Format:	Article
Language:	English
Published:	Elsevier 2017-04-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231716302853

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