Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes

Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes

Abstract Background Detection of DNA copy number alterations (CNAs) is critical to understand genetic diversity, genome evolution and pathological conditions such as cancer. Cancer genomes are plagued with widespread multi-level structural aberrations of chromosomes that pose challenges to discover...

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Bibliographic Details
Main Authors: Ahmed Ibrahim Samir Khalil, Costerwell Khyriem, Anupam Chattopadhyay, Amartya Sanyal
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Bioinformatics
Subjects:
Cancer
DNA copy number alteration
Focal amplification and deletion
Segmental aneuploidy
Genome sequence analysis
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Online Access:http://link.springer.com/article/10.1186/s12859-020-3480-3

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http://link.springer.com/article/10.1186/s12859-020-3480-3

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