Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial and sporadic Parkinson's disease (PD). An increase in copper (Cu) levels has been reported in the cerebrospinal fluid and blood of PD patients, while occupational exposure to Cu has been suggested to aug...

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Bibliographic Details
Main Authors: Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M. Griggs, Laura Zavala-Flores, Elsa M. Reyes-Reyes, Javier Seravalli, Lia A. Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk, Rodrigo Franco
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
A53T
Autophagy
Proteasome
Ubiquitination
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003647

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http://www.sciencedirect.com/science/article/pii/S0969996114003647

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