The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance

The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance

Protein tyrosine phosphatase 1B (PTP1B), which can directly dephosphorylate both the insulin receptor and insulin receptor substrate 1 (IRS-1), thereby terminating insulin signaling, reportedly plays an important role in insulin resistance. Accumulating evidence has demonstrated that O-GlcNAc modifi...

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Bibliographic Details
Main Authors: Yun Zhao, Zhuqi Tang, Aiguo Shen, Tao Tao, Chunhua Wan, Xiaohui Zhu, Jieru Huang, Wanlu Zhang, Nana Xia, Suxin Wang, Shiwei Cui, Dongmei Zhang
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
insulin resistance
PTP1B
O-GlcNAc
Online Access:http://www.mdpi.com/1422-0067/16/9/22856

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http://www.mdpi.com/1422-0067/16/9/22856

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