Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model
It has been proposed that Alzheimer disease (AD) is associated with a “disconnection syndrome” due to the gradual loss of morphological and functional integrity of cortico-cortical pathways. This hypothesis derives from indirect neuropathological observations, but definitive evidence that AD primari...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2004-06-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104000130 |