Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration.

In addition to cochleotoxicity, systemic aminoglycoside pharmacotherapy causes vestibulotoxicity resulting in imbalance and visual dysfunction. The underlying trafficking routes of systemically-administered aminoglycosides from the vasculature to the vestibular sensory hair cells are largely unknown...

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Bibliographic Details
Main Authors: Jianping Liu, Allan Kachelmeier, Chunfu Dai, Hongzhe Li, Peter S Steyger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368668?pdf=render