Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics.

Muscle invasive bladder cancer (MIBC, stage ≥T2) is generally associated with poor prognosis, constituting the second most common cause of death among genitourinary tumours. Due to high molecular heterogeneity significant variations in the natural history and disease outcome have been observed. This...

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Main Authors: Céu Costa, Sofia Pereira, Luís Lima, Andreia Peixoto, Elisabete Fernandes, Diogo Neves, Manuel Neves, Cristiana Gaiteiro, Ana Tavares, Rui M Gil da Costa, Ricardo Cruz, Teresina Amaro, Paula A Oliveira, José Alexandre Ferreira, Lúcio L Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0141253