Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9

Wnt/β-catenin signaling elicits context-dependent transcription switches that determine normal development and oncogenesis. These are mediated by the Wnt enhanceosome, a multiprotein complex binding to the Pygo chromatin reader and acting through TCF/LEF-responsive enhancers. Pygo renders this compl...

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Bibliographic Details
Main Authors: Laurens M van Tienen, Juliusz Mieszczanek, Marc Fiedler, Trevor J Rutherford, Mariann Bienz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
BCL9/Legless
Wnt signalling pathway
Wnt enhanceosome complex
nuclear co-receptor complex
Osa/ARID1A
Groucho/TLE
Online Access:https://elifesciences.org/articles/20882

Internet

https://elifesciences.org/articles/20882

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