Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

Treatment With the Delta Opioid Agonist UFP-512 Alleviates Chronic Inflammatory and Neuropathic Pain: Mechanisms Implicated

We investigated whether administration of the δ-opioid receptor (DOR) agonist H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), which also activates nuclear factor erythroid 2-related factor 2 (Nrf2), alleviated chronic inflammatory and/or neuropathic pain and inhibited the depressive-like behaviors associat...

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Bibliographic Details
Main Authors: Sara Polo, Andrés Felipe Díaz, Núria Gallardo, Sergi Leánez, Gianfranco Balboni, Olga Pol
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
analgesia
depression
Nrf2 transcription factor
delta opioid receptors
oxidative stress
chronic pain
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00283/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00283/full

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