Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes

Background: Insulin has been demonstrated to exert direct and indirect effects on vascular tissues. Its actions in vascular cells are mediated by two major pathways: the insulin receptor substrate 1/2-phosphoinositide-3 kinase/Akt (IRS1/2/PI3K/Akt) pathway and the Src/mitogen-activated protein kinas...

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Bibliographic Details
Main Authors: Jialin Fu, Marc Gregory Yu, Qian Li, Kyoungmin Park, George L. King
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Molecular Metabolism
Subjects:
CVD
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000818