HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia

Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority of CRC patients, cachexia remains underserved, understudied and uncured. Animal models for the study of CRC-induced cachexia, in particular mo...

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Bibliographic Details
Main Authors: Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto
Format: Article
Language:English
Published: The Company of Biologists 2020-01-01
Series:Disease Models & Mechanisms
Subjects:
colorectal cancer
liver metastases
hct116
cachexia
stat3
skeletal muscle
Online Access:http://dmm.biologists.org/content/13/1/dmm043166

Internet

http://dmm.biologists.org/content/13/1/dmm043166

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