Novel d-γ-tocopherol derivative as a prodrug for d-γ-tocopherol and a two-step prodrug for S-γ-CEHC

d-γ-Tocopherol (γ-T230) and its major metabolite, 2, 7, 8-trimethyl-2S-(β-carboxyethyl)-6-hydroxychroman (S-γ-CEHC), are currently receiving attention concerning their unique pharmacological activities. In order to achieve the efficient delivery of γ-Toc and S-γ-CEHC in vivo, we synthesized d-γ-toco...

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Bibliographic Details
Main Authors: Jiro Takata, Ryoji Hidaka, Akihiko Yamasaki, Akihiro Hattori, Takeshi Fukushima, Maiko Tanabe, Kazuhisa Matsunaga, Yoshiharu Karube, Kazuhiro Imai
Format: Article
Language:English
Published: Elsevier 2002-12-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520327498