Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons

Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons

The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury. However, it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death. By comparing the survival rate and morphology of primary neurons and SH-SY5Y cells exposed to erastin, it was...

Full description

Bibliographic Details
Main Authors: Yan Zhang, Bao-You Fan, Yi-Lin Pang, Wen-Yuan Shen, Xu Wang, Chen-Xi Zhao, Wen-Xiang Li, Chang Liu, Xiao-Hong Kong, Guang-Zhi Ning, Shi-Qing Feng, Xue Yao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
cystine/glutamate antiporter system light chain; deferoxamine; erastin; ferroptosis; glutathione peroxidase 4; neurons; neuroprotection; reactive oxygen species
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1539;epage=1545;aulast=Zhang

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=8;spage=1539;epage=1545;aulast=Zhang

Similar Items