New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients

A genetic diagnosis facilitates personalized cancer treatment and clinical care of relatives at risk, however, although 25% of colorectal cancer cases are familial, around 95% of the families are genetically unresolved. In this study, we performed gene panel analysis on germline DNA of 32 establishe...

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Bibliographic Details
Main Authors: Malene Djursby, Majbritt B. Madsen, Jane H. Frederiksen, Lukas A. Berchtold, Christina Therkildsen, Gro L. Willemoe, Jane P. Hasselby, Friedrik Wikman, Henrik Okkels, Anne-Bine Skytte, Mef Nilbert, Karin Wadt, Anne-Marie Gerdes, Thomas van Overeem Hansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Genetics
Subjects:
hereditary colorectal cancer
gene panel analysis
familial cancer
oligogenic inheritance
early onset colorectal cancer
RPS20
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.566266/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.566266/full

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