Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli

Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli

Cyclic dinucleotides (CDNs) are widely used secondary signaling molecules in bacterial and mammalian cells. The family of CDNs includes c-di-GMP, c-di-AMP and two distinct versions of hybrid cGAMPs. Studies related to these CDNs require large doses that are relatively expensive to generate by curren...

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Bibliographic Details
Main Authors: Yun Lv, Qichao Sun, Xiaodan Wang, Yi Lu, Yaoyao Li, Huiqing Yuan, Jing Zhu, Deyu Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
cyclic dinucleotides
dinucleotide cyclases
microbial preparation
affinity purification
adjuvant
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02111/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02111/full

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