Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells

Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells

Hypoxia and the accumulation of hypoxia-inducible factors (HIFs) in tumors have been associated with therapeutic resistance and with autophagy establishment. We examined the effects of stable knockdown of HIF-1α or HIF-2α expression on autophagy and drug resistance in colon cancer...

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Bibliographic Details
Main Authors: Abril Saint-Martin, Jacobo Martínez-Ríos, M. Cristina Castañeda-Patlán, Miguel Angel Sarabia-Sánchez, Nydia Tejeda-Muñoz, Alberto Chinney-Herrera, Gloria Soldevila, Roberto Benelli, Paula Santoyo-Ramos, Alessandro Poggi, Martha Robles-Flores
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
colon cancer
hypoxia-inducible factors
drug resistance
autophagy
Online Access:https://www.mdpi.com/2072-6694/11/6/755

Internet

https://www.mdpi.com/2072-6694/11/6/755

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