Rapamycin Protects Skin Fibroblasts from Ultraviolet B-Induced Photoaging by Suppressing the Production of Reactive Oxygen Species

Rapamycin Protects Skin Fibroblasts from Ultraviolet B-Induced Photoaging by Suppressing the Production of Reactive Oxygen Species

Background/Aims: Ultraviolet B (UVB) irradiation alters multiple molecular pathways in the skin, thereby inducing skin photoaging. Murine dermal fibroblasts (MDFs) were subjected to a series of 4 sub-cytotoxic UVB doses (120 mJ/cm2), resulting in changes in cell shape, DNA damage, cell cycle arrest,...

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Bibliographic Details
Main Authors: Dengke Qin, Runjian Ren, Chuanlong Jia, Yongzhou Lu, Qingjian Yang, Liang Chen, Xinyuan Wu, Jingjing Zhu, Yu Guo, Ping Yang, Yiqun Zhou, Ningwen Zhu, Bo Bi, Tianyi Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Uvb
ROS
Rapamycin
Autophagy
Online Access:https://www.karger.com/Article/FullText/489369

Internet

https://www.karger.com/Article/FullText/489369

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