In Vitro Effects of VA441, a New Selective Cyclooxygenase-2 Inhibitor, on Human Osteoarthritic Chondrocytes exposed to IL-1β

The aim of this in vitro study was to examine the possible effect of [2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)]-1H-pyrrole (VA441), a new selective cyclooxygenase (COX)-2 inhibitor, on human osteoarthritic (OA) chondrocyte cultivated in the presence or absence of interleu...

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Main Authors: Antonella Fioravanti, Laura Tinti, Nicola Antonio Pascarelli, Angela Di Capua, Antonello Lamboglia, Andrea Cappelli, Mariangela Biava, Antonio Giordani, Silvia Niccolini, Mauro Galeazzi, Maurizio Anzini
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319304591