Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction

Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction

Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor binding site, the authors synthesized a small...

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Bibliographic Details
Main Authors: Stefano Toldo, PhD, Dana Austin, MS, Adolfo G. Mauro, MS, Eleonora Mezzaroma, PhD, Benjamin W. Van Tassell, PharmD, Carlo Marchetti, PhD, Salvatore Carbone, MS, Soren Mogelsvang, PhD, Cohava Gelber, PhD, Antonio Abbate, MD, PhD
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:JACC: Basic to Translational Science
Subjects:
ischemia reperfusion
low-density lipoprotein receptor-related protein-1
serine protease inhibitor
SERPINs
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17302024

Internet

http://www.sciencedirect.com/science/article/pii/S2452302X17302024

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