Inhibitory monoclonal antibodies against mouse proteases raised in gene-deficient mice block proteolytic functions in vivo

Inhibitory monoclonal antibodies against mouse proteases raised in gene-deficient mice block proteolytic functions in vivo

Identification of targets for cancer therapy requires the understanding of the in vivo roles of proteins, which can be derived from studies using gene-targeted mice. An alternative strategy is the administration of inhibitory monoclonal antibodies (mAbs), causing acute disruption of the target prote...

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Bibliographic Details
Main Authors: Ida Katrine Lund, Morten Grønbech Rasch, Signe eIngvarsen, Jesper ePass, Daniel H Madsen, Lars H Engelholm, Niels eBehrendt, Gunilla eHøyer-Hansen
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Pharmacology
Subjects:
extracellular proteolysis
collagen internalization
in vivo models
Mouse monoclonal antibodies
plasminogen activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00122/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00122/full

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