Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

Abstract Background In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA...

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Bibliographic Details
Main Authors: Sandra Pérez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont, Raquel Largo
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Inflammation
Subjects:
Rheumatoid arthritis
Synovitis
Janus kinase inhibitors
Tofacitinib
Online Access:http://link.springer.com/article/10.1186/s12950-019-0206-2

Internet

http://link.springer.com/article/10.1186/s12950-019-0206-2

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