Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic activity of target proteins via inhibition of act...

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Bibliographic Details
Main Authors: Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Neurobiology of Disease
Subjects:
Nitrosative stress
Nitric oxide
Reactive nitrogen species
S-Nitrosylation
Protein misfolding
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000893

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http://www.sciencedirect.com/science/article/pii/S0969996115000893

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