Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium.

Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium.

Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function. In the current paper, we demonstrate that TRPV4 is fu...

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Bibliographic Details
Main Authors: Kevin Monaghan, Jennifer McNaughten, Mary K McGahon, Catriona Kelly, Daniel Kyle, Phaik Har Yong, J Graham McGeown, Tim M Curtis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4457535?pdf=render

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http://europepmc.org/articles/PMC4457535?pdf=render

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