Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance

Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance

Objective: Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), play a paramount role in the central regulation of energy balance. Despite the substantial body of genetic evidence implicating BDNF- or TrkB-deficiency in human obesity, the critical brain re...

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Bibliographic Details
Main Authors: Ceren Ozek, Derek J. Zimmer, Bart C. De Jonghe, Robert G. Kalb, Kendra K. Bence
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Molecular Metabolism
Subjects:
TrkB
BDNF
Hypothalamus
Hindbrain
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001568

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http://www.sciencedirect.com/science/article/pii/S2212877815001568

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