MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47

MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47

Abstract Immunoevasion is a hallmark of cancer progression, and immune checkpoint blockade has emerged as a promising strategy for cancer treatment. microRNAs (miRNAs) are important negative regulators of gene expression in the immune system. Here, we demonstrate that miR-708 regulates CD47, a trans...

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Bibliographic Details
Main Authors: Wei Huang, Wen-Tao Wang, Ke Fang, Zhen-Hua Chen, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Xue-Qun Luo, Yue-Qin Chen
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cancer
Subjects:
miR-708
CD47
T-cell acute lymphoblastic leukemia
Targeted therapies
Online Access:http://link.springer.com/article/10.1186/s12943-018-0768-2

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http://link.springer.com/article/10.1186/s12943-018-0768-2

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