Fc Receptor Inhibition Reduces Susceptibility to Oxidative Stress in Human RPE Cells Treated with Bevacizumab, but not Aflibercept

Fc Receptor Inhibition Reduces Susceptibility to Oxidative Stress in Human RPE Cells Treated with Bevacizumab, but not Aflibercept

Background/Aims: VEGF-A is induced by oxidative stress, and functions as a survival factor for various cell types, including retinal pigment epithelial (RPE) cells. Anti-vascular endothelial growth factor (VEGF) drugs like aflibercept and bevacizumab have shown to be most effective in treating neova...

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Bibliographic Details
Main Authors: Mahdy Ranjbar, Max Philipp Brinkmann, Dorinja Zapf, Yoko Miura, Martin Rudolf, Salvatore Grisanti
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
VEGF-A
Aflibercept
Bevacizumab
FcR
Oxidative stress
ROS
Online Access:http://www.karger.com/Article/FullText/443030

Internet

http://www.karger.com/Article/FullText/443030

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