Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents

Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.

Bibliographic Details
Main Authors: Thomas J. Clough, Lijun Jiang, Ka-Leung Wong, Nicholas J. Long
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09342-3