Metformin and berberine prevent olanzapine-induced weight gain in rats.

Metformin and berberine prevent olanzapine-induced weight gain in rats.

Olanzapine is a first line medication for the treatment of schizophrenia, but it is also one of the atypical antipsychotics carrying the highest risk of weight gain. Metformin was reported to produce significant attenuation of antipsychotic-induced weight gain in patients, while the study of prevent...

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Bibliographic Details
Main Authors: Yueshan Hu, Alan J Young, Erik A Ehli, Dustin Nowotny, Paige S Davies, Elizabeth A Droke, Timothy J Soundy, Gareth E Davies
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3965561?pdf=render

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http://europepmc.org/articles/PMC3965561?pdf=render

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