Intracellular Na<sup>+</sup> Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An <i>In Silico</i> Analysis

Intracellular Na<sup>+</sup> Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An <i>In Silico</i> Analysis

<i>Background</i>: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart’s primary pacemaker, are incompletely understood. Electrical and Ca<sup>2+</sup>-handling remodeling have been implicated in SAN dysfunction associated with heart failure, aging,...

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Bibliographic Details
Main Authors: Stefano Morotti, Haibo Ni, Colin H. Peters, Christian Rickert, Ameneh Asgari-Targhi, Daisuke Sato, Alexey V. Glukhov, Catherine Proenza, Eleonora Grandi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
sodium homeostasis
sodium/potassium pump
sodium/calcium exchanger
sinoatrial node
coupled-clock system
cardiomyocyte
Online Access:https://www.mdpi.com/1422-0067/22/11/5645

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https://www.mdpi.com/1422-0067/22/11/5645

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