Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice

Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice

Leucine-rich repeat kinase 2 (LRRK2) is genetically implicated in both familial and sporadic Parkinson's disease (PD). Moreover, LRRK2 has emerged as a compelling therapeutic target for the treatment of PD. Consequently, there is much interest in understanding LRRK2 and its role in PD pathogene...

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Bibliographic Details
Main Authors: Ye Zhao, Shikara Keshiya, Farzaneh Atashrazm, Jianqun Gao, Lars M. Ittner, Dario R. Alessi, Glenda M. Halliday, Yuhong Fu, Nicolas Dzamko
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Neurobiology of Disease
Subjects:
LRRK2
Phosphorylation
α-Synuclein
Knockin mouse
Striatum
Astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118302225

Internet

http://www.sciencedirect.com/science/article/pii/S0969996118302225

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