Proteasome dysfunction in aged human α-synuclein transgenic mice
A deficit in proteasome function in Parkinson's disease has been speculated. We characterized the ubiquitin–proteasome system in three regions of brain from transgenic and nontransgenic littermates. Mice expressing a doubly mutated form of human α-synuclein had significant impairments whereas m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2006-07-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996106000386 |