Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes

Rabphilin involvement in filtration and molecular uptake in Drosophila nephrocytes suggests a similar role in human podocytes

Drosophila nephrocytes share functional, structural and molecular similarities with human podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex, and its expression is altered in mouse and human proteinuric disease. Furthermore, we previously identified a polymorphism t...

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Bibliographic Details
Main Authors: Estela Selma-Soriano, Beatriz Llamusi, Juan Manuel Fernández-Costa, Lauren Louise Ozimski, Rubén Artero, Josep Redón
Format: Article
Language:English
Published: The Company of Biologists 2020-09-01
Series:Disease Models & Mechanisms
Subjects:
drosophila nephrocyte
rabphilin
endocytic pathway
chronic kidney disease
slit diaphragm
labyrinthine channels
Online Access:http://dmm.biologists.org/content/13/9/dmm041509

Internet

http://dmm.biologists.org/content/13/9/dmm041509

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