Evaluation of the antigen-experienced B-cell receptor repertoire in healthy children and adults

Evaluation of the antigen-experienced B-cell receptor repertoire in healthy children and adults

Upon antigen recognition via their B cell receptor (BR) B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and class switch recombination (CSR) to change the effector function of the secreted antibodies. These steps are e...

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Bibliographic Details
Main Authors: Hanna IJspeert, Pauline A. van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen, Andrew P. Stubbs, Mirjam van der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Immunoglobulins
next generation sequencing
Class switch recombination
somatic hypermutation
repertoire
Reference data set
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00410/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00410/full

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