Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER

Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER

Microsomal triglyceride transfer protein (MTP) is an intraluminal protein in the endoplasmic reticulum (ER) that is essential for the assembly of apolipoprotein B (apoB)-containing lipoproteins. In this study, we examine how the livers of mice respond to two distinct methods of blocking MTP function...

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Bibliographic Details
Main Authors: Wei Liao, To Y. Hui, Stephen G. Young, Roger A. Davis
Format: Article
Language:English
Published: Elsevier 2003-05-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein B
endoplasmic reticulum
hyperlipidemia
liver
inflammation
unfolded protein response
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311433

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http://www.sciencedirect.com/science/article/pii/S0022227520311433

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