Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE-/- Mice

Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE-/- Mice

Background: Although our previous studies have confirmed that the activation of TLR4 is implicated in the development of atherosclerosis induced by chronic unpredicted mild stress (CUMS), the underling mechanism is largely unclear. Here, we hypothesized that CUMS accelerates atherosclerotic developm...

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Bibliographic Details
Main Authors: Hong-Feng Gu, Na Li, Zhao-Qian Xu, Lu Hu, Hui Li, Rong-Jie Zhang, Ru-Meng Chen, Xi-Long Zheng, Ya-Ling Tang, Duan-Fang Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
chronic stress
atherosclerosis
inflammation
HMGB1
toll-like receptor 4
ABCA1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00165/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00165/full

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