Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans

Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to P. falciparum Transmission-Blocking Candidate Pfs25 in Humans

Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen have shown promise in mice but the same efficacy has never been achieved in humans. We have previously published pre-clinical data related to a TBV candidate Pfs25-IMX313 encoded in viral vectors which was very p...

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Bibliographic Details
Main Authors: Marija Zaric, Arianna Marini, Carolyn M. Nielsen, Gaurav Gupta, David Mekhaiel, Thao P. Pham, Sean C. Elias, Iona J. Taylor, Hans de Graaf, Ruth O. Payne, Yuanyuan Li, Sarah E. Silk, Chris Williams, Adrian V. S. Hill, Carole A. Long, Kazutoyo Miura, Sumi Biswas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
CD4+
Pfs25
P. falciparum
transmission blocking
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.732667/full

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