Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR

Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR

Abstract Human blood group A and B glycosyltransferases (GTA, GTB) are retaining glycosyltransferases, requiring a catalytic mechanism that conserves the anomeric configuration of the hexopyranose moiety of the donor substrate (UDP‐GalNAc, UDP‐Gal). Previous studies have shown that GTA and GTB cycle...

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Bibliographic Details
Main Authors: Dr. Friedemann Flügge, Prof. Dr. Thomas Peters
Format: Article
Language:English
Published: Wiley-VCH 2019-06-01
Series:ChemistryOpen
Subjects:
glycosyltransferase
Methyl TROSY
chemical shift perturbation
allosteric effects
binding kinetics
Online Access:https://doi.org/10.1002/open.201900116

Internet

https://doi.org/10.1002/open.201900116

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