Sirolimus alters lung pathology and viral load following influenza A virus infection

Sirolimus alters lung pathology and viral load following influenza A virus infection

Abstract Background Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role of this serine/threonine kinase in ameliorating lung inflammation. Other studies have shown sirolimus reduces/delays lung...

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Bibliographic Details
Main Authors: Ahmed R. Alsuwaidi, Junu A. George, Saeeda Almarzooqi, Stacey M. Hartwig, Steven M. Varga, Abdul-Kader Souid
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Respiratory Research
Subjects:
Rapamycin
Influenza A virus
Viral replication
Inflammatory score
Lung function
Online Access:http://link.springer.com/article/10.1186/s12931-017-0618-6

Internet

http://link.springer.com/article/10.1186/s12931-017-0618-6

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