Blood-brain barrier genetic disruption leads to protective barrier formation at the Glia Limitans.

Inflammation of the central nervous system (CNS) induces endothelial blood-brain barrier (BBB) opening as well as the formation of a tight junction barrier between reactive astrocytes at the Glia Limitans. We hypothesized that the CNS parenchyma may acquire protection from the reactive astrocytic Gl...

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Bibliographic Details
Main Authors: Pierre Mora, Pierre-Louis Hollier, Sarah Guimbal, Alice Abelanet, Aïssata Diop, Lauriane Cornuault, Thierry Couffinhal, Sam Horng, Alain-Pierre Gadeau, Marie-Ange Renault, Candice Chapouly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000946