Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease

Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and...

Full description

Bibliographic Details
Main Authors: Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Biggs
Format: Article
Language:English
Published: Nature Publishing Group 2017-01-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-016-0004-y