Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and...
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2017-01-01
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doaj-f22c5328fdf74dc0b1ae3c8bb9fca3a32020-12-08T14:15:30ZengNature Publishing Groupnpj Parkinson's Disease2373-80572017-01-01311510.1038/s41531-016-0004-yExcessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s diseaseDominic J Hare0Bárbara Rita Cardoso1Erika P Raven2Kay L Double3David I Finkelstein4Ewa A Szymlek-Gay5Beverley-Ann Biggs6Department of Medicine (Royal Melbourne Hospital) at the Doherty Institute, The University of MelbourneThe Florey Institute of Neuroscience and Mental Health, The University of MelbourneCenter for Functional and Molecular Imaging, Georgetown University Medical CentreSydney Medical School, University of SydneyThe Florey Institute of Neuroscience and Mental Health, The University of MelbourneInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin UniversityDepartment of Medicine (Royal Melbourne Hospital) at the Doherty Institute, The University of MelbourneAbstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals.https://doi.org/10.1038/s41531-016-0004-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs |
spellingShingle |
Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease npj Parkinson's Disease |
author_facet |
Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs |
author_sort |
Dominic J Hare |
title |
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease |
title_short |
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease |
title_full |
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease |
title_fullStr |
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease |
title_full_unstemmed |
Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease |
title_sort |
excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for parkinson’s disease |
publisher |
Nature Publishing Group |
series |
npj Parkinson's Disease |
issn |
2373-8057 |
publishDate |
2017-01-01 |
description |
Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals. |
url |
https://doi.org/10.1038/s41531-016-0004-y |
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