Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition

Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition

NAFLD is an important public health issue closely associated with the pervasive epidemics of diabetes and obesity. Yet, despite NAFLD being among the most common of chronic liver diseases, the biological factors responsible for its transition from benign nonalcoholic fatty liver (NAFL) to NASH remai...

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Bibliographic Details
Main Authors: Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phillip B. Hylemon, Huiping Zhou, William M. Pandak
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Lipid Research
Subjects:
cholesterol toxicity
oxysterol 7α-hydroxylase
inflammation
liver injury
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520600244

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http://www.sciencedirect.com/science/article/pii/S0022227520600244

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