CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex

The human αβ T-cell receptor (TCR) is composed of a variable heterodimer (TCRαβ) and three invariant dimers (CD3γε, CD3δε, and ζζ/CD2472). The role of each invariant chain in the stepwise interactions among TCR chains along the assembly is still not fully understood. Despite the high sequence homolo...

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Bibliographic Details
Main Authors: Beatriz Garcillán, Patricia Fuentes, Ana V. Marin, Rebeca F. Megino, Daniel Chacon-Arguedas, Marina S. Mazariegos, Anaïs Jiménez-Reinoso, Miguel Muñoz-Ruiz, Raquel G. Laborda, Paula P. Cárdenas, Edgar Fernández-Malavé, Maria L. Toribio, José R. Regueiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD3G
CD3D
shRNA knockdown
T-cell receptor (TCR)
TCR assembly
T-cell progenitors
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.608490/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.608490/full

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