Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

Background/AimHypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating cardiovascular diseases. However, the role of the imm...

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Bibliographic Details
Main Authors: Wen Yan, Zhi-Chao Dong, Jing-Jing Wang, Yun-Long Zhang, Hong-Xia Wang, Bo Zhang, Hui-Hua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
cardiac hypertrophy
immunoproteasome subunit
LMP10
ATG7
autophagy
gp130
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00625/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00625/full

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