Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways

Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways

Abstract Background Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathways. Though routine quantification of direct oral anticoagulants (DOACs)...

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Bibliographic Details
Main Authors: Andrea Huppertz, Caspar Grond-Ginsbach, Chris Dumschat, Kathrin I. Foerster, Jürgen Burhenne, Johanna Weiss, David Czock, Jan C. Purrucker, Timolaos Rizos, Walter E. Haefeli
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
Direct oral anticoagulants
Apixaban
Plasma concentration
Neurology
Online Access:http://link.springer.com/article/10.1186/s40360-019-0331-9

Internet

http://link.springer.com/article/10.1186/s40360-019-0331-9

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