Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5.

BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, has recently shown antitumor activity in various cancer cells. Apo2 ligand or tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is regarded as a promising anticancer agent, but chemoresistance affec...

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Bibliographic Details
Main Authors: Rui Kong, Guang Jia, Zhuo-xin Cheng, Yong-wei Wang, Ming Mu, Shuang-jia Wang, Shang-ha Pan, Yue Gao, Hong-chi Jiang, De-li Dong, Bei Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3364248?pdf=render

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http://europepmc.org/articles/PMC3364248?pdf=render

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