The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134–142 of the ABCG5/ABCG8 intergenic region necessary for the activi...

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Bibliographic Details
Main Authors: Lita A. Freeman, Arion Kennedy, Justina Wu, Samantha Bark, Alan T. Remaley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr.
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter
CPF
liver receptor homolog-1
FTF
FXR
SHP
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317764

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http://www.sciencedirect.com/science/article/pii/S0022227520317764

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