Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade

Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade

Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation (HSCT). We herein show that, mechanistically, SSA...

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Bibliographic Details
Main Authors: Danika M. Khong, Jarrod A. Dudakov, Maree V. Hammett, Marc I. Jurblum, Sacha M.L. Khong, Gabrielle L. Goldberg, Tomoo Ueno, Lisa Spyroglou, Lauren F. Young, Marcel R.M. van den Brink, Richard L. Boyd, Ann P. Chidgey
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115000399

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http://www.sciencedirect.com/science/article/pii/S2213671115000399

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